On a 4×4 grid you use the numbers 1, 2, 3 and 4.
A cage of two squares marked "3+" must hold 1 and 2, because 1 + 2 = 3. Which goes where depends on the rest of the grid.
A cage marked "2÷" could hold 1 and 2, or 2 and 4, because the bigger number divided by the smaller one is 2.
A cage marked "1−" holds two numbers next to each other, such as 3 and 4.
A cage of one square marked "4" is simply 4. Fill those first.

